5fnf
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Dynamic Undocking and the Quasi-Bound State as tools for Drug Design== | |
| - | + | <StructureSection load='5fnf' size='340' side='right' caption='[[5fnf]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fnf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FNF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQL:4-[(E)-N-OXIDANYL-C-PYRIDIN-3-YL-CARBONIMIDOYL]BENZENE-1,3-DIOL'>TQL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fnc|5fnc]], [[5fnd|5fnd]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnf OCA], [http://pdbe.org/5fnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnf RCSB], [http://www.ebi.ac.uk/pdbsum/5fnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baker, L M]] | ||
| + | [[Category: Barril, X]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
| + | [[Category: Hubbard, R]] | ||
| + | [[Category: Luque, F J]] | ||
| + | [[Category: Matassova, N]] | ||
[[Category: Murray, J]] | [[Category: Murray, J]] | ||
| + | [[Category: Roughley, S]] | ||
[[Category: Ruiz-Carmona, S]] | [[Category: Ruiz-Carmona, S]] | ||
| - | [[Category: Hubbard, R]] | ||
| - | [[Category: Barril, X]] | ||
| - | [[Category: Matassova, N]] | ||
[[Category: Schmidtke, P]] | [[Category: Schmidtke, P]] | ||
| - | [[Category: | + | [[Category: Chaperone]] |
| - | [[Category: | + | [[Category: Drug design]] |
| - | [[Category: | + | [[Category: Hsp90]] |
| + | [[Category: Oncology]] | ||
Revision as of 10:50, 10 December 2016
Dynamic Undocking and the Quasi-Bound State as tools for Drug Design
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Categories: Baker, L M | Barril, X | Davis, B | Hubbard, R | Luque, F J | Matassova, N | Murray, J | Roughley, S | Ruiz-Carmona, S | Schmidtke, P | Chaperone | Drug design | Hsp90 | Oncology
