5g6v
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the PCTAIRE1 kinase in complex with inhibitor== | |
| - | + | <StructureSection load='5g6v' size='340' side='right' caption='[[5g6v]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G6V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [http://pdbe.org/5g6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [http://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cyclin-dependent kinase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bartual, S Galan]] | ||
| + | [[Category: Bountra, C]] | ||
[[Category: Bullock, A]] | [[Category: Bullock, A]] | ||
| + | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Dixon-Clarke, S E]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Elkins, J]] | [[Category: Elkins, J]] | ||
| - | [[Category: | + | [[Category: Heroven, C]] |
| - | [[Category: | + | [[Category: Kopec, J]] |
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[[Category: Mackenzie, A]] | [[Category: Mackenzie, A]] | ||
| - | [[Category: | + | [[Category: Savitsky, P]] |
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[[Category: Tallant, C]] | [[Category: Tallant, C]] | ||
| - | [[Category: | + | [[Category: Transferase]] |
Revision as of 10:51, 10 December 2016
Crystal structure of the PCTAIRE1 kinase in complex with inhibitor
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