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5t6f
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==1.90 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (orthorhombic P form)== | |
| - | + | <StructureSection load='5t6f' size='340' side='right' caption='[[5t6f]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T6F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N38:3-CYCLOHEXYL-N-{(2S)-1-HYDROXY-3-[(3S)-2-OXOPYRROLIDIN-3-YL]PROPAN-2-YL}-N~2~-{[3-(4-METHOXYPHENOXY)PROPYL]SULFONYL}-L-ALANINAMIDE'>N38</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t6d|5t6d]], [[5t6g|5t6g]]</td></tr> |
| - | [[Category: Chang, K | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t6f OCA], [http://pdbe.org/5t6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t6f RCSB], [http://www.ebi.ac.uk/pdbsum/5t6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t6f ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68]] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Alsoudi, A F]] | ||
| + | [[Category: Battaile, K P]] | ||
| + | [[Category: Chang, K O]] | ||
| + | [[Category: Damalanka, V C]] | ||
| + | [[Category: Dissanayake, D M.P]] | ||
| + | [[Category: Doyle, S T]] | ||
| + | [[Category: Groutas, W C]] | ||
| + | [[Category: Kankanamalage, A C.G]] | ||
| + | [[Category: Kim, Y]] | ||
[[Category: Lovell, S]] | [[Category: Lovell, S]] | ||
| - | [[Category: Damalanka, V.C]] | ||
| - | [[Category: Groutas, W.C]] | ||
[[Category: Mehzabeen, N]] | [[Category: Mehzabeen, N]] | ||
| - | [[Category: | + | [[Category: Rathnayake, A D]] |
| - | [[Category: | + | [[Category: Weerawarna, P M]] |
| + | [[Category: Antiviral inhibitor]] | ||
| + | [[Category: Dipeptidyl inhibitor]] | ||
| + | [[Category: Norovirus]] | ||
| + | [[Category: Norwalk virus]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Protease-protease inhibitor complex]] | ||
Revision as of 10:58, 10 December 2016
1.90 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (orthorhombic P form)
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Categories: Alsoudi, A F | Battaile, K P | Chang, K O | Damalanka, V C | Dissanayake, D M.P | Doyle, S T | Groutas, W C | Kankanamalage, A C.G | Kim, Y | Lovell, S | Mehzabeen, N | Rathnayake, A D | Weerawarna, P M | Antiviral inhibitor | Dipeptidyl inhibitor | Norovirus | Norwalk virus | Protease | Protease-protease inhibitor complex
