This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1qmw
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1qmw |SIZE=350|CAPTION= <scene name='initialview01'>1qmw</scene> | |PDB= 1qmw |SIZE=350|CAPTION= <scene name='initialview01'>1qmw</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Janes, R W.]] | [[Category: Janes, R W.]] | ||
[[Category: Whitford, D.]] | [[Category: Whitford, D.]] | ||
| - | [[Category: NH2]] | ||
[[Category: conotoxin]] | [[Category: conotoxin]] | ||
[[Category: nicotinic acetylcholine receptor]] | [[Category: nicotinic acetylcholine receptor]] | ||
| Line 33: | Line 35: | ||
[[Category: venom]] | [[Category: venom]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:07 2008'' |
Revision as of 20:16, 30 March 2008
| |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI
Overview
The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of alpha-conotoxin GI. Surprisingly, a high degree of similarity between the backbone conformations of the GI crystal and the SI solution structures is seen in the region of lowest sequence homology, namely residues Gly-8 to Ser-12. This similarity is more surprising when considering that in SI a proline replaces the Arg-9 found in GI. The correspondence in conformation in this region provides the definitive evidence that it is the loss of the arginine basic charge at residue 9 which determines the differences in toxicity between GI and SI, rather than any changes in conformation induced by the cyclic proline residue.
About this Structure
1QMW is a Single protein structure of sequence from Conus striatus. Full crystallographic information is available from OCA.
Reference
Solution structure of alpha-conotoxin SI., Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW, FEBS Lett. 2000 Jul 7;476(3):287-95. PMID:10913630
Page seeded by OCA on Sun Mar 30 23:16:07 2008
