5ezu

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'''Unreleased structure'''
 
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The entry 5ezu is ON HOLD until Paper Publication
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==Crystal structure of the N-terminal domain of vaccinia virus immunomodulator A46 in complex with myristic acid.==
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<StructureSection load='5ezu' size='340' side='right' caption='[[5ezu]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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Authors: Fedosyuk, S., Bezerra, G.A., Sammito, M., Uson, I., Skern, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ezu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EZU FirstGlance]. <br>
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Description: Crystal structure of the N-terminal domain of vaccinia virus immunomodulator A46 in complex with myristic acid.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ezu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezu OCA], [http://pdbe.org/5ezu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezu RCSB], [http://www.ebi.ac.uk/pdbsum/5ezu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezu ProSAT]</span></td></tr>
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[[Category: Uson, I]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A46_VACCW A46_VACCW]] Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation.
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__TOC__
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</StructureSection>
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[[Category: Bezerra, G A]]
[[Category: Fedosyuk, S]]
[[Category: Fedosyuk, S]]
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[[Category: Sammito, M]]
[[Category: Skern, T]]
[[Category: Skern, T]]
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[[Category: Bezerra, G.A]]
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[[Category: Uson, I]]
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[[Category: Sammito, M]]
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[[Category: A46]]
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[[Category: Ab initio phasing]]
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[[Category: Beta sheet]]
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[[Category: Fatty acid]]
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[[Category: Immunomodulator]]
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[[Category: Myristic acid]]
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[[Category: Vaccinia virus]]
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[[Category: Viral protein]]

Revision as of 18:31, 10 December 2016

Crystal structure of the N-terminal domain of vaccinia virus immunomodulator A46 in complex with myristic acid.

5ezu, resolution 1.55Å

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