We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

5sw9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5sw9" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5sw9 is ON HOLD
+
==The structure of the PP2A B56 subunit RepoMan complex==
-
 
+
<StructureSection load='5sw9' size='340' side='right' caption='[[5sw9]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5sw9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SW9 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5swf|5swf]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sw9 OCA], [http://pdbe.org/5sw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sw9 RCSB], [http://www.ebi.ac.uk/pdbsum/5sw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sw9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Bajaj, R]]
 +
[[Category: Page, R]]
 +
[[Category: Peti, W]]
 +
[[Category: Wang, X]]
 +
[[Category: Cell cycle]]
 +
[[Category: Hydrolase]]
 +
[[Category: Phosphatase]]
 +
[[Category: Regulator]]
 +
[[Category: Slim]]

Revision as of 18:38, 10 December 2016

The structure of the PP2A B56 subunit RepoMan complex

5sw9, resolution 2.85Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5sw9"
Personal tools