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5swf
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the PP2A B56 subunit double phosphorylated BubR1 complex== |
| - | + | <StructureSection load='5swf' size='340' side='right' caption='[[5swf]], [[Resolution|resolution]] 2.82Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5swf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SWF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5sw9|5sw9]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5swf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5swf OCA], [http://pdbe.org/5swf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5swf RCSB], [http://www.ebi.ac.uk/pdbsum/5swf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5swf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bajaj, R]] | ||
[[Category: Page, R]] | [[Category: Page, R]] | ||
| + | [[Category: Peti, W]] | ||
[[Category: Wang, X]] | [[Category: Wang, X]] | ||
| - | [[Category: | + | [[Category: Cell cycle]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| + | [[Category: Phosphatase]] | ||
| + | [[Category: Regulator]] | ||
| + | [[Category: Slim]] | ||
Revision as of 18:38, 10 December 2016
The structure of the PP2A B56 subunit double phosphorylated BubR1 complex
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Categories: Bajaj, R | Page, R | Peti, W | Wang, X | Cell cycle | Hydrolase | Phosphatase | Regulator | Slim
