5lzs

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'''Unreleased structure'''
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{{Large structure}}
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==Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B==
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<StructureSection load='5lzs' size='340' side='right' caption='[[5lzs]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lzs]] is a 86 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C4:(2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-BUTAN-2-YL]-20-[(4-METHOXYPHENYL)METHYL]-6,17,21-TRIMETHYL-3-(2-METHYLPROPYL)-12-OXIDANYL-2,5,7,10,15,19,22-HEPTAKIS(OXIDANYLIDENE)-8-PROPAN-2-YL-9,18-DIOXA-1,4,14,21-TETRAZABICYCLO[21.3.0]HEXACOSAN-16-YL]AMINO]-4-METHYL-1-OXIDANYLIDENE-PENTAN-2-YL]-~{N}-METHYL-1-[(2~{S})-2-OXIDANYLPROPANOYL]PYRROLIDINE-2-CARBOXAMIDE'>7C4</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzs OCA], [http://pdbe.org/5lzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzs RCSB], [http://www.ebi.ac.uk/pdbsum/5lzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzs ProSAT]</span></td></tr>
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</table>
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{{Large structure}}
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== Function ==
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[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] [[http://www.uniprot.org/uniprot/EF1A1_RABIT EF1A1_RABIT]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structures of the mammalian ribosome engaged with decoding factorGTPase complexes representing intermediates of translation elongation (aminoacyl-tRNAeEF1A), termination (eRF1eRF3), and ribosome rescue (PelotaHbs1l). Comparative analyses reveal that each decoding factor exploits the plasticity of the ribosomal decoding center to differentially remodel ribosomal proteins and rRNA. This leads to varying degrees of large-scale ribosome movements and implies distinct mechanisms for communicating information from the decoding center to each GTPase. Additional structural snapshots of the translation termination pathway reveal the conformational changes that choreograph the accommodation of decoding factors into the peptidyl transferase center. Our results provide a structural framework for how different states of the mammalian ribosome are selectively recognized by the appropriate decoding factorGTPase complex to ensure translational fidelity.
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The entry 5lzs is ON HOLD
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Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.,Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS Cell. 2016 Nov 17;167(5):1229-1240.e15. doi: 10.1016/j.cell.2016.10.046. PMID:27863242<ref>PMID:27863242</ref>
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Authors:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description:
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<div class="pdbe-citations 5lzs" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Oryctolagus cuniculus]]
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[[Category: Brown, A]]
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[[Category: Hegde, R S]]
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[[Category: Murray, J]]
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[[Category: Ramakrishnan, V]]
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[[Category: Shao, S]]
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[[Category: Taunton, J]]
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[[Category: Elongation]]
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[[Category: Ribosome]]
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[[Category: Translation]]

Revision as of 18:39, 10 December 2016

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Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B

5lzs, resolution 3.31Å

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