4agq

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==Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196==
==Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196==
<StructureSection load='4agq' size='340' side='right' caption='[[4agq]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
<StructureSection load='4agq' size='340' side='right' caption='[[4agq]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4agq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AGQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4agq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AGQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P96:2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-6-IODO-4-[3-(PHENYLAMINO)PROP-1-YN-1-YL]PHENOL'>P96</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P96:2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-6-IODO-4-[3-(PHENYLAMINO)PROP-1-YN-1-YL]PHENOL'>P96</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2biq|2biq]], [[1dt7|1dt7]], [[2ybg|2ybg]], [[1uol|1uol]], [[2j1x|2j1x]], [[2foj|2foj]], [[2b3g|2b3g]], [[2bin|2bin]], [[1olh|1olh]], [[1tsr|1tsr]], [[1pes|1pes]], [[2j21|2j21]], [[2gs0|2gs0]], [[2j0z|2j0z]], [[2x0v|2x0v]], [[1c26|1c26]], [[1sal|1sal]], [[1kzy|1kzy]], [[1xqh|1xqh]], [[2fej|2fej]], [[1a1u|1a1u]], [[2ahi|2ahi]], [[2wgx|2wgx]], [[3sak|3sak]], [[1saf|1saf]], [[2foo|2foo]], [[2bio|2bio]], [[2ydr|2ydr]], [[1olg|1olg]], [[2bip|2bip]], [[2j11|2j11]], [[1pet|1pet]], [[2j1y|2j1y]], [[1jsp|1jsp]], [[1ma3|1ma3]], [[2x0w|2x0w]], [[2xwr|2xwr]], [[2vuk|2vuk]], [[1aie|1aie]], [[1saj|1saj]], [[2h1l|2h1l]], [[1tup|1tup]], [[1hs5|1hs5]], [[2ata|2ata]], [[2x0u|2x0u]], [[1ycq|1ycq]], [[1gzh|1gzh]], [[1sah|1sah]], [[2bim|2bim]], [[1ycr|1ycr]], [[1sak|1sak]], [[2j10|2j10]], [[2ady|2ady]], [[1sae|1sae]], [[2j1z|2j1z]], [[4ago|4ago]], [[1ycs|1ycs]], [[2ac0|2ac0]], [[2j20|2j20]], [[1h26|1h26]], [[2j1w|2j1w]], [[4agp|4agp]], [[4agl|4agl]], [[4agn|4agn]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2biq|2biq]], [[1dt7|1dt7]], [[2ybg|2ybg]], [[1uol|1uol]], [[2j1x|2j1x]], [[2foj|2foj]], [[2b3g|2b3g]], [[2bin|2bin]], [[1olh|1olh]], [[1tsr|1tsr]], [[1pes|1pes]], [[2j21|2j21]], [[2gs0|2gs0]], [[2j0z|2j0z]], [[2x0v|2x0v]], [[1c26|1c26]], [[1sal|1sal]], [[1kzy|1kzy]], [[1xqh|1xqh]], [[2fej|2fej]], [[1a1u|1a1u]], [[2ahi|2ahi]], [[2wgx|2wgx]], [[3sak|3sak]], [[1saf|1saf]], [[2foo|2foo]], [[2bio|2bio]], [[2ydr|2ydr]], [[1olg|1olg]], [[2bip|2bip]], [[2j11|2j11]], [[1pet|1pet]], [[2j1y|2j1y]], [[1jsp|1jsp]], [[1ma3|1ma3]], [[2x0w|2x0w]], [[2xwr|2xwr]], [[2vuk|2vuk]], [[1aie|1aie]], [[1saj|1saj]], [[2h1l|2h1l]], [[1tup|1tup]], [[1hs5|1hs5]], [[2ata|2ata]], [[2x0u|2x0u]], [[1ycq|1ycq]], [[1gzh|1gzh]], [[1sah|1sah]], [[2bim|2bim]], [[1ycr|1ycr]], [[1sak|1sak]], [[2j10|2j10]], [[2ady|2ady]], [[1sae|1sae]], [[2j1z|2j1z]], [[4ago|4ago]], [[1ycs|1ycs]], [[2ac0|2ac0]], [[2j20|2j20]], [[1h26|1h26]], [[2j1w|2j1w]], [[4agp|4agp]], [[4agl|4agl]], [[4agn|4agn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4agq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4agq RCSB], [http://www.ebi.ac.uk/pdbsum/4agq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4agq OCA], [http://pdbe.org/4agq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4agq RCSB], [http://www.ebi.ac.uk/pdbsum/4agq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4agq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4agq" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Boeckler, F M]]
[[Category: Boeckler, F M]]
[[Category: Fersht, A R]]
[[Category: Fersht, A R]]

Revision as of 18:56, 10 December 2016

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196

4agq, resolution 1.42Å

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