5gjs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of H1 hemagglutinin from A/California/04/2009 in complex with a neutralizing antibody 3E1== | |
| - | + | <StructureSection load='5gjs' size='340' side='right' caption='[[5gjs]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5gjs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GJS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gjt|5gjt]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjs OCA], [http://pdbe.org/5gjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gjs RCSB], [http://www.ebi.ac.uk/pdbsum/5gjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjs ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ding, J]] | [[Category: Ding, J]] | ||
[[Category: Wang, W]] | [[Category: Wang, W]] | ||
| + | [[Category: Zhang, T]] | ||
| + | [[Category: Complementarity determining region]] | ||
| + | [[Category: Epitope]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Paratope]] | ||
Revision as of 02:11, 11 December 2016
Crystal structure of H1 hemagglutinin from A/California/04/2009 in complex with a neutralizing antibody 3E1
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