5iek

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'''Unreleased structure'''
 
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The entry 5iek is ON HOLD until Paper Publication
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==Structure of HLA-B*40:02 in complex with the endogenous peptide REFSKEPEL==
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<StructureSection load='5iek' size='340' side='right' caption='[[5iek]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Alpizar, A., Marcilla, M., Santiago, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5iek]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IEK FirstGlance]. <br>
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Description: Structure of HLA-B*40:02 in complex with the endogenous peptide REFSKEPEL
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iek OCA], [http://pdbe.org/5iek PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iek RCSB], [http://www.ebi.ac.uk/pdbsum/5iek PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iek ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1B40_HUMAN 1B40_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Alpizar, A]]
[[Category: Alpizar, A]]
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[[Category: Marcilla, M]]
[[Category: Santiago, C]]
[[Category: Santiago, C]]
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[[Category: Marcilla, M]]
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[[Category: Human leukocyte antigen system]]
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[[Category: Immune system]]

Revision as of 02:13, 11 December 2016

Structure of HLA-B*40:02 in complex with the endogenous peptide REFSKEPEL

5iek, resolution 1.80Å

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