5k6s

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'''Unreleased structure'''
 
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The entry 5k6s is ON HOLD until Paper Publication
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==The structure of the PP2A B56 subunit BubR1 complex==
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<StructureSection load='5k6s' size='340' side='right' caption='[[5k6s]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5k6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K6S FirstGlance]. <br>
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Description:
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6s OCA], [http://pdbe.org/5k6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k6s RCSB], [http://www.ebi.ac.uk/pdbsum/5k6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bajaj, R]]
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[[Category: Page, R]]
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[[Category: Peti, W]]
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[[Category: Wang, X]]
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[[Category: Cell cycle]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]
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[[Category: Regulator]]
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[[Category: Slim]]

Revision as of 02:15, 11 December 2016

The structure of the PP2A B56 subunit BubR1 complex

5k6s, resolution 2.79Å

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