5lrn

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m (Protected "5lrn" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5lrn is ON HOLD until Paper Publication
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==Structure of mono-zinc MCR-1 in P21 space group==
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<StructureSection load='5lrn' size='340' side='right' caption='[[5lrn]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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Authors: Hinchliffe, P., Paterson, N.G., Spencer, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lrn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRN FirstGlance]. <br>
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Description: Structure of mono-zinc MCR-1 in P21 space group
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lrn OCA], [http://pdbe.org/5lrn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lrn RCSB], [http://www.ebi.ac.uk/pdbsum/5lrn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lrn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX]] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Hinchliffe, P]]
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[[Category: Paterson, N G]]
[[Category: Spencer, J]]
[[Category: Spencer, J]]
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[[Category: Paterson, N.G]]
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[[Category: Antibiotic resistance]]
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[[Category: Hinchliffe, P]]
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[[Category: Colistin]]
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[[Category: Metalloenzyme]]
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[[Category: Phosphotehanolamine]]
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[[Category: Transferase]]

Revision as of 02:17, 11 December 2016

Structure of mono-zinc MCR-1 in P21 space group

5lrn, resolution 1.55Å

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