5m72
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human SRP68-72 protein-binding domain complex== | |
| - | + | <StructureSection load='5m72' size='340' side='right' caption='[[5m72]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5m72]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M72 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m72 OCA], [http://pdbe.org/5m72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m72 RCSB], [http://www.ebi.ac.uk/pdbsum/5m72 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m72 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Autosomal dominant aplasia and myelodysplasia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. [[http://www.uniprot.org/uniprot/SRP68_HUMAN SRP68_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Becker, M M.M]] | ||
| + | [[Category: Sinning, I]] | ||
[[Category: Wild, K]] | [[Category: Wild, K]] | ||
| - | [[Category: | + | [[Category: Protein targeting]] |
| - | [[Category: | + | [[Category: Protein transport]] |
| + | [[Category: Protein-peptide complex]] | ||
| + | [[Category: Signal recognition particle]] | ||
| + | [[Category: Tetratricopeptide repeat]] | ||
Revision as of 02:18, 11 December 2016
Structure of the human SRP68-72 protein-binding domain complex
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