5m73
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human SRP S domain with SRP72 RNA-binding domain== | |
| - | + | <StructureSection load='5m73' size='340' side='right' caption='[[5m73]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5m73]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M73 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m73 OCA], [http://pdbe.org/5m73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m73 RCSB], [http://www.ebi.ac.uk/pdbsum/5m73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m73 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Autosomal dominant aplasia and myelodysplasia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. [[http://www.uniprot.org/uniprot/SRP68_HUMAN SRP68_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. [[http://www.uniprot.org/uniprot/SRP19_HUMAN SRP19_HUMAN]] Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Becker, M M.M]] | ||
| + | [[Category: Sinning, I]] | ||
[[Category: Wild, K]] | [[Category: Wild, K]] | ||
| - | [[Category: | + | [[Category: Protein targeting]] |
| - | [[Category: | + | [[Category: Protein-rna complex]] |
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Rna kink-turn]] | ||
| + | [[Category: Signal recognition particle]] | ||
Revision as of 02:18, 11 December 2016
Structure of the human SRP S domain with SRP72 RNA-binding domain
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