1qqe
From Proteopedia
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB]</span> | ||
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[[Category: helix-turn-helix tpr-like repeat]] | [[Category: helix-turn-helix tpr-like repeat]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:17:29 2008'' |
Revision as of 20:17, 30 March 2008
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| , resolution 2.90Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17
Overview
SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of an N-terminal twisted sheet of alpha-helical hairpins and a C-terminal alpha-helical bundle. The N-terminal sheet has local similarity to the tetratricopeptide repeats from protein phosphatase 5 but has a different overall twist. Sec17 also shares structural features with HEAT and clathrin heavy chain repeats. Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes.
About this Structure
1QQE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassembly., Rice LM, Brunger AT, Mol Cell. 1999 Jul;4(1):85-95. PMID:10445030
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