4e71
From Proteopedia
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==Crystal structure of the RHO GTPASE binding domain of Plexin B2== | ==Crystal structure of the RHO GTPASE binding domain of Plexin B2== | ||
<StructureSection load='4e71' size='340' side='right' caption='[[4e71]], [[Resolution|resolution]] 2.26Å' scene=''> | <StructureSection load='4e71' size='340' side='right' caption='[[4e71]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E71 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLXNB2, KIAA0315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLXNB2, KIAA0315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [http://www.ebi.ac.uk/pdbsum/4e71 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [http://pdbe.org/4e71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [http://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 02:38, 11 December 2016
Crystal structure of the RHO GTPASE binding domain of Plexin B2
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Categories: Human | Arrowsmith, C H | Bountra, C | Edwards, A M | Guan, X | Park, H | Structural genomic | Tempel, W | Tong, Y | Wang, H | Weigelt, J | Plexin | Rbd | Sgc | Signaling | Signaling protein | Transmembrane
