4b8b
From Proteopedia
(Difference between revisions)
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==N-Terminal domain of the yeast Not1== | ==N-Terminal domain of the yeast Not1== | ||
<StructureSection load='4b8b' size='340' side='right' caption='[[4b8b]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4b8b' size='340' side='right' caption='[[4b8b]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4b8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4b8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8B FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b89|4b89]], [[4b8a|4b8a]], [[4b8c|4b8c]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b89|4b89]], [[4b8a|4b8a]], [[4b8c|4b8c]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8b RCSB], [http://www.ebi.ac.uk/pdbsum/4b8b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8b OCA], [http://pdbe.org/4b8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b8b RCSB], [http://www.ebi.ac.uk/pdbsum/4b8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8b ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NOT1_YEAST NOT1_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4b8b" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Baker's yeast]] |
[[Category: Basquin, J]] | [[Category: Basquin, J]] | ||
[[Category: Conti, E]] | [[Category: Conti, E]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 02:40, 11 December 2016
N-Terminal domain of the yeast Not1
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