Urokinase

(Difference between revisions)

Revision as of 09:11, 11 December 2016

Human urokinase short chain (grey) and catalytic domain (green) complex with iodobenzine inhibitor and citrate, 1c5w

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Updated on 11-December-2016

↑ Carriero MV, Stoppelli MP. The urokinase-type plasminogen activator and the generation of inhibitors of urokinase activity and signaling. Curr Pharm Des. 2011;17(19):1944-61. PMID:21711235

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 <StructureSection load='1c5w' size='340' side='right' caption='Human urokinase short chain (grey) and catalytic domain (green) complex with iodobenzine inhibitor and citrate, [[1c5w]]' scene='' >
 == Function ==
-'''Urokinase''' (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin<ref>PMID:15454079</ref>.  UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains.  Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178).
+'''Urokinase''' (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin<ref>PMID:21711235</ref>.  UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains.  Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178).
 </StructureSection>
 == 3D Structures of urokinase ==