Vinculin
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1st6| PDB=1st6 | SIZE=400| SCENE= |right|CAPTION=Chicken full-length metavinculin, [[1st6]] }} | ||
| + | <StructureSection load='1st6' size='340' side='right' caption='Chicken full-length metavinculin, [[1st6]]' scene='' > | ||
[[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. '''Metavinculin''' is a splice version of VCL containing an extra ca. 70 amino acids in the C-terminal domain. | [[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. '''Metavinculin''' is a splice version of VCL containing an extra ca. 70 amino acids in the C-terminal domain. | ||
| - | + | </StructureSection> | |
== 3D Structures of Vinculin == | == 3D Structures of Vinculin == | ||
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**[[4e17]], [[4e18]] - cm-VCL Vd1 + catenin α-1 VCL-binding domain | **[[4e17]], [[4e18]] - cm-VCL Vd1 + catenin α-1 VCL-binding domain | ||
}} | }} | ||
| + | ==References== | ||
| + | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
*Created with the participation of [[User:Susan Craig|Susan Craig]]. | *Created with the participation of [[User:Susan Craig|Susan Craig]]. | ||
Revision as of 09:11, 13 December 2016
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3D Structures of Vinculin
Updated on 13-December-2016
References
- Created with the participation of Susan Craig.
