Folylpolyglutamate synthase

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Revision as of 10:59, 15 December 2016

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spinqualitylabelsall models Folypolyglutamate synthase complex with ADP and AMPPCP (PDB code 2vor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Folypolyglutamate synthase (FPGS) is active in intracellular folate homeostasis. Polyglutamated folates are substrates for generation of the primary metyhl group donor S-adenosylmethionine (SAM)[1]. Disease Relevance FPGS status is a predictor of chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate based chemotherapy and FPGS gene transfer may increase the sensitivity of colon cancer cells to 5-FU-based chemotherapy[2]. Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

3D structures of folypolyglutamate synthase

Updated on 15-December-2016

• Folypolyglutamate synthase

• • 3nrs – YpFPGS/dihydrofolate synthase – Yersinia pestis
    
  • 1o5z – FPGS – Thermotoga maritima
    
  • 2gca – LcFPGS – Lactobacillus casei
    

• Folypolyglutamate synthase complex

• • 3qcz – YpFPGS/dihydrofolate synthase + AMPPNP + Mn + glutamate
    
  • 3pyz – YpFPGS/dihydrofolate synthase + AMPPNP + Mn
    
  • 3n2a – YpFPGS/dihydrofolate synthase + ADP + Mg
    
  • 2vor – MtFPGS + ADP + AMPPNP – Mycobacterium tuberculosis
    
  • 2vos – MtFPGS + ADP
    
  • 2gc5, 2gc6, 2gcb – FPGS (mutant)
    
  • 1w78 – EcFPGS + ADP + DHPP – Escherichia coli
    
  • 1w7k – EcFPGS + ADP
    
  • 1jbv – LcFPGS + AMPPCP
    
  • 1jbw – LcFPGS + AMPPCP + folate derivative
    
  • 1fgs – LcFPGS + pyrophosphate
    

References

1. ↑ Kim SE, Hinoue T, Kim MS, Sohn KJ, Cho RC, Weisenberger DJ, Laird PW, Kim YI. Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. J Nutr Biochem. 2016 Mar;29:27-35. doi: 10.1016/j.jnutbio.2015.10.019. Epub 2015 , Nov 17. PMID:26895662 doi:http://dx.doi.org/10.1016/j.jnutbio.2015.10.019
2. ↑ Sohn KJ, Smirnakis F, Moskovitz DN, Novakovic P, Yates Z, Lucock M, Croxford R, Kim YI. Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. Gut. 2004 Dec;53(12):1825-31. PMID:15542523 doi:http://dx.doi.org/10.1136/gut.2004.042713