3uid
From Proteopedia
(Difference between revisions)
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<StructureSection load='3uid' size='340' side='right' caption='[[3uid]], [[Resolution|resolution]] 1.57Å' scene=''> | <StructureSection load='3uid' size='340' side='right' caption='[[3uid]], [[Resolution|resolution]] 1.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3uid]] is a 2 chain structure | + | <table><tr><td colspan='2'>[[3uid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UID FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uid OCA], [http://pdbe.org/3uid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uid RCSB], [http://www.ebi.ac.uk/pdbsum/3uid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uid ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uid OCA], [http://pdbe.org/3uid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uid RCSB], [http://www.ebi.ac.uk/pdbsum/3uid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uid ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of Msmeg_6760, a protein of unknown function, has been determined. Biochemical and bioinformatics analyses determined that Msmeg_6760 interacts with a protein encoded in the same operon, Msmeg_6762, and predicted that the operon is a toxin-antitoxin (TA) system. Structural comparison of Msmeg_6760 with proteins of known function suggests that Msmeg_6760 binds a hydrophobic ligand in a buried cavity lined by large hydrophobic residues. Access to this cavity could be controlled by a gate-latch mechanism. The function of the Msmeg_6760 toxin is unknown, but structure-based predictions revealed that Msmeg_6760 and Msmeg_6762 are homologous to Rv2034 and Rv2035, a predicted novel TA system involved in Mycobacterium tuberculosis latency during macrophage infection. The Msmeg_6760 toxin fold has not been previously described for bacterial toxins and its unique structural features suggest that toxin activation is likely to be mediated by a novel mechanism. | ||
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| + | Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response.,Bajaj RA, Arbing MA, Shin A, Cascio D, Miallau L Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):863-869. Epub 2016, Nov 19. PMID:27917833<ref>PMID:27917833</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3uid" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Mycs2]] | ||
[[Category: Arbing, M]] | [[Category: Arbing, M]] | ||
[[Category: Bajaj, R A]] | [[Category: Bajaj, R A]] | ||
Revision as of 11:18, 15 December 2016
Crystal Structure of Protein Ms6760 from Mycobacterium smegmatis
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