5f8z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1== |
| - | + | <StructureSection load='5f8z' size='340' side='right' caption='[[5f8z]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5f8z]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj4 4zj4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F8Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f8t|5f8t]], [[5f8x|5f8x]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8z OCA], [http://pdbe.org/5f8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8z RCSB], [http://www.ebi.ac.uk/pdbsum/5f8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[http://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Plasma kallikrein]] | ||
[[Category: Andreasen, P]] | [[Category: Andreasen, P]] | ||
| - | [[Category: Xu, P]] | ||
| - | [[Category: Xu, M]] | ||
[[Category: Huang, M]] | [[Category: Huang, M]] | ||
[[Category: Jiang, L]] | [[Category: Jiang, L]] | ||
[[Category: Luo, Z]] | [[Category: Luo, Z]] | ||
| + | [[Category: Xu, M]] | ||
| + | [[Category: Xu, P]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor]] | ||
| + | [[Category: Peptide inhibitor]] | ||
Revision as of 18:57, 15 December 2016
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1
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