5gqr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PXY-CLE41-SERK2== | |
| + | <StructureSection load='5gqr' size='340' side='right' caption='[[5gqr]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5gqr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GQR FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqr OCA], [http://pdbe.org/5gqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gqr RCSB], [http://www.ebi.ac.uk/pdbsum/5gqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TDR_ARATH TDR_ARATH]] Acts with CLE41p and CLE44p peptides as a ligand-receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins.<ref>PMID:17570668</ref> <ref>PMID:18812507</ref> [[http://www.uniprot.org/uniprot/SERK2_ARATH SERK2_ARATH]] Serine/threonine-kinase involved in brassinosteroid-dependent and -independent signaling pathways. Acts redundantly with SERK1 as a control point for sporophytic development controlling male gametophyte production.<ref>PMID:18667726</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In Arabidopsis, the CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) peptides play important roles in regulating proliferation and differentiation of plant-specific stem cells. Although receptors of CLEs are reported to be leucine-rich repeat receptor kinases, the mechanisms underlying CLE-induced receptor activation remain largely unknown. Here we show that SOMATIC EMBRYOGENESIS RECEPTOR KINASEs (SERKs) serve as co-receptors in CLE41/TDIF-PXY signaling to regulate plant vascular development. TDIF induces interaction of its receptor PXY with SERKs in vitro and in vivo. Furthermore, the serk1-1 serk2-1 bak1-5 mutant plants are less sensitive to TDIF, phenocopying the pxy mutant with a compromised promotion of procambial cell proliferation. Crystal structure of the PXY-TDIF-SERK2 complex reveals that the last amino acid of TDIF conserved among CLEs and other evolutionary-related peptides is important for the interaction between SERK2 and PXY. Taken together, our current study identifies SERKs as signaling components of the TDIF-PXY pathway and suggests a conserved activation mechanism of CLE receptors. | ||
| - | + | SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development.,Zhang H, Lin X, Han Z, Wang J, Qu LJ, Chai J Mol Plant. 2016 Oct 10;9(10):1406-1414. doi: 10.1016/j.molp.2016.07.004. Epub, 2016 Jul 21. PMID:27449136<ref>PMID:27449136</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Chai, J | + | <div class="pdbe-citations 5gqr" style="background-color:#fffaf0;"></div> |
| - | [[Category: Zhang, H | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Chai, J J]] | ||
| + | [[Category: Zhang, H Q]] | ||
| + | [[Category: Cle peptide]] | ||
| + | [[Category: Leucine rich repeat]] | ||
| + | [[Category: Meristem cell proliferation]] | ||
| + | [[Category: Serk]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 18:58, 15 December 2016
Crystal structure of PXY-CLE41-SERK2
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