2n3y
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state== | |
| - | + | <StructureSection load='2n3y' size='340' side='right' caption='[[2n3y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n3y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MH0:MESOHEME'>MH0</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PA:4-(CARBOXYMETHYL)-L-PHENYLALANINE'>1PA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3y OCA], [http://pdbe.org/2n3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3y RCSB], [http://www.ebi.ac.uk/pdbsum/2n3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CYC_HUMAN CYC_HUMAN]] Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:[http://omim.org/entry/612004 612004]]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.<ref>PMID:18345000</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CYC_HUMAN CYC_HUMAN]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conte, R Del]] | ||
[[Category: Diaz-Moreno, I]] | [[Category: Diaz-Moreno, I]] | ||
[[Category: Diaz-Quintana, A]] | [[Category: Diaz-Quintana, A]] | ||
| - | [[Category: Del Conte, R]] | ||
[[Category: Moreno-Beltran, B]] | [[Category: Moreno-Beltran, B]] | ||
| + | [[Category: Rosa, M A.De la]] | ||
[[Category: Turano, P]] | [[Category: Turano, P]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| + | [[Category: Cytochrome c]] | ||
| + | [[Category: Electron transport]] | ||
| + | [[Category: Hemeprotein]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Phosphorylation]] | ||
Revision as of 19:12, 15 December 2016
NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state
| |||||||||||
