5fpg

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'''Unreleased structure'''
 
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The entry 5fpg is ON HOLD until Paper Publication
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==Crystal structure of human tankyrase 2 in complex with TA-92==
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<StructureSection load='5fpg' size='340' side='right' caption='[[5fpg]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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Authors: Haikarainen, T., Lehtio, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fpg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPG FirstGlance]. <br>
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Description: Crystal structure of human tankyrase 2 in complex with TA-92
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Q28:4-[3-(8-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2-+YL)PROPANAMIDO]-N-(QUINOLIN-8-YL)BENZAMIDE'>Q28</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fpf|5fpf]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpg OCA], [http://pdbe.org/5fpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpg RCSB], [http://www.ebi.ac.uk/pdbsum/5fpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Haikarainen, T]]
[[Category: Lehtio, L]]
[[Category: Lehtio, L]]
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[[Category: Haikarainen, T]]
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[[Category: Adp- ribosylation]]
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[[Category: Diphtheria toxin like fold]]
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[[Category: Protein-ligand complex]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 19:15, 15 December 2016

Crystal structure of human tankyrase 2 in complex with TA-92

5fpg, resolution 2.75Å

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