5h2w
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340)== | |
| - | + | <StructureSection load='5h2w' size='340' side='right' caption='[[5h2w]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h2w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H2W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h2x|5h2x]], [[5h2v|5h2v]]</td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ulp1_peptidase Ulp1 peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.68 3.4.22.68] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h2w OCA], [http://pdbe.org/5h2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h2w RCSB], [http://www.ebi.ac.uk/pdbsum/5h2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h2w ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IMA1_YEAST IMA1_YEAST]] Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).<ref>PMID:7565597</ref> <ref>PMID:10913188</ref> <ref>PMID:21075847</ref> [[http://www.uniprot.org/uniprot/ULP1_YEAST ULP1_YEAST]] Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle.<ref>PMID:10094048</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ulp1 peptidase]] | ||
| + | [[Category: Hirano, H]] | ||
| + | [[Category: Matsuura, Y]] | ||
| + | [[Category: Nuclear import]] | ||
| + | [[Category: Protein transport-hydrolase complex]] | ||
Revision as of 19:16, 15 December 2016
Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340)
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