5j26
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant== | |
| - | + | <StructureSection load='5j26' size='340' side='right' caption='[[5j26]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j26]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J26 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j26 OCA], [http://pdbe.org/5j26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j26 RCSB], [http://www.ebi.ac.uk/pdbsum/5j26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j26 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Canny, M]] | ||
[[Category: Durocher, D]] | [[Category: Durocher, D]] | ||
| - | [[Category: Juang, Y | + | [[Category: Juang, Y C]] |
| + | [[Category: Sicheri, F]] | ||
[[Category: Wan, L]] | [[Category: Wan, L]] | ||
| - | [[Category: | + | [[Category: Protein binding]] |
| - | [[Category: | + | [[Category: Tudor domain ubiquitin variant]] |
Revision as of 19:18, 15 December 2016
Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant
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