This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5tpz
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state== | |
| - | + | <StructureSection load='5tpz' size='340' side='right' caption='[[5tpz]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tpz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TPZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpz OCA], [http://pdbe.org/5tpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tpz RCSB], [http://www.ebi.ac.uk/pdbsum/5tpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Furukawa, H]] | ||
| + | [[Category: Karakas, E]] | ||
| + | [[Category: Romero-Hernandez, A]] | ||
| + | [[Category: Simorwski, N]] | ||
| + | [[Category: Allosteric modulation]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Nmda receptor]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 19:21, 15 December 2016
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state
| |||||||||||
