1qxb

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|PDB= 1qxb |SIZE=350|CAPTION= <scene name='initialview01'>1qxb</scene>
|PDB= 1qxb |SIZE=350|CAPTION= <scene name='initialview01'>1qxb</scene>
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=RIB:RIBOSE'>RIB</scene>
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=RIB:RIBOSE'>RIB</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxb OCA], [http://www.ebi.ac.uk/pdbsum/1qxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qxb RCSB]</span>
}}
}}
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[[Category: Rozenski, J.]]
[[Category: Rozenski, J.]]
[[Category: Vastmans, K.]]
[[Category: Vastmans, K.]]
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[[Category: RIB]]
 
[[Category: b-helix]]
[[Category: b-helix]]
[[Category: backbone modification]]
[[Category: backbone modification]]
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[[Category: ribose]]
[[Category: ribose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:43:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:17 2008''

Revision as of 20:20, 30 March 2008


PDB ID 1qxb

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Ligands: , , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9


Overview

A ribose residue inserted between the 3'-OH of one nucleotide and the 5'-phosphate group of the next nucleotide, functions as a site-specific cleavage site within DNA. This extra ribose does not interrupt helix formation and it protects duplex DNA against cleavage by restriction enzymes. Cleavage can be obtained with periodate and all ribose fragments can be removed with sodium hydroxide. As a result of this, an intact natural oligodeoxynucleotide is obtained after ligation reaction, which means that site-specific cleavage and recovering of intact DNA occurs without loss of genetic information.

About this Structure

1QXB is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside., Nauwelaerts K, Vastmans K, Froeyen M, Kempeneers V, Rozenski J, Rosemeyer H, Van Aerschot A, Busson R, Lacey JC, Efimtseva E, Mikhailov S, Lescrinier E, Herdewijn P, Nucleic Acids Res. 2003 Dec 1;31(23):6758-69. PMID:14627809

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