4ghu

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==Crystal structure of TRAF3/Cardif==
==Crystal structure of TRAF3/Cardif==
<StructureSection load='4ghu' size='340' side='right' caption='[[4ghu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4ghu' size='340' side='right' caption='[[4ghu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ghu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GHU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ghu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GHU FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Traf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Traf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ghu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ghu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ghu RCSB], [http://www.ebi.ac.uk/pdbsum/4ghu PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ghu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ghu OCA], [http://pdbe.org/4ghu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ghu RCSB], [http://www.ebi.ac.uk/pdbsum/4ghu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ghu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRAF3_MOUSE TRAF3_MOUSE]] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:16306936</ref> <ref>PMID:16306937</ref> <ref>PMID:17015635</ref> <ref>PMID:17158868</ref> <ref>PMID:18313334</ref> <ref>PMID:18997792</ref> <ref>PMID:18997794</ref> <ref>PMID:19228877</ref> <ref>PMID:19898473</ref> <ref>PMID:8934568</ref> [[http://www.uniprot.org/uniprot/MAVS_MOUSE MAVS_MOUSE]] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ghu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TNF receptor-associated factor|TNF receptor-associated factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
[[Category: Zhang, P]]
[[Category: Zhang, P]]
[[Category: Alpha/beta]]
[[Category: Alpha/beta]]

Revision as of 19:55, 15 December 2016

Crystal structure of TRAF3/Cardif

4ghu, resolution 2.20Å

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