1qys
From Proteopedia
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|PDB= 1qys |SIZE=350|CAPTION= <scene name='initialview01'>1qys</scene>, resolution 2.50Å | |PDB= 1qys |SIZE=350|CAPTION= <scene name='initialview01'>1qys</scene>, resolution 2.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qys OCA], [http://www.ebi.ac.uk/pdbsum/1qys PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qys RCSB]</span> | ||
}} | }} | ||
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[[Category: novel fold]] | [[Category: novel fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:53 2008'' |
Revision as of 20:20, 30 March 2008
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| , resolution 2.50Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Top7: A computationally designed protein with a novel fold
Overview
A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue alpha/beta protein called Top7 with a novel sequence and topology. Top7 was found experimentally to be folded and extremely stable, and the x-ray crystal structure of Top7 is similar (root mean square deviation equals 1.2 angstroms) to the design model. The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe not yet observed in nature.
About this Structure
1QYS is a Protein complex structure of sequences from Computationally designed sequence. The following page contains interesting information on the relation of 1QYS with [Designer Proteins]. Full crystallographic information is available from OCA.
Reference
Design of a novel globular protein fold with atomic-level accuracy., Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science. 2003 Nov 21;302(5649):1364-8. PMID:14631033
Page seeded by OCA on Sun Mar 30 23:20:53 2008
