Poliovirus receptor-related protein
From Proteopedia
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| - | <StructureSection load='4myw' size='340' side='right' caption=' | + | <StructureSection load='4myw' size='340' side='right' caption='Poliovirus receptor-related protein 1 (green) complex with herpes virus envelope glycoprotein (grey) (PDB code [[4myw]])' scene=''> |
== Function == | == Function == | ||
| - | '''Poliovirus receptor-related protein''' (PVRP) or '''Nectin''' are membrane glycoproteins belonging to the immunoglobulin family | + | '''Poliovirus receptor-related protein''' (PVRP) or '''Nectin''' are membrane glycoproteins belonging to the immunoglobulin family.<br /> |
*'''PVRP-1''' mediates Ca+2-independent cell adhesion<ref>PMID:09616127</ref>.<br /> | *'''PVRP-1''' mediates Ca+2-independent cell adhesion<ref>PMID:09616127</ref>.<br /> | ||
| - | *'''PVRP-2''' and '''PVRP-3''' are components of the adherens junction.<br /> | + | *'''PVRP-2''' and '''PVRP-3''' are components of the adherens junction<ref>PMID:9845526</ref>.<br /> |
*'''PVRP-4''' binds PVRP-1.<br /> | *'''PVRP-4''' binds PVRP-1.<br /> | ||
== Relevance == | == Relevance == | ||
PVRP-4 is involved in tumor cell migration. | PVRP-4 is involved in tumor cell migration. | ||
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| - | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 10:44, 18 December 2016
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3D structures of poliovirus receptor-related protein
Updated on 18-December-2016
References
- ↑ Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science. 1998 Jun 5;280(5369):1618-20. PMID:9616127
- ↑ Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood. 1998 Dec 15;92(12):4602-11. PMID:9845526
