2-isopropylmalate synthase

From Proteopedia

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Revision as of 10:46, 19 December 2016

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function 2-isopropylmalate synthase (LeuA) or α-isopropylmalate synthase catalyzes the reversible conversion of 3-methyl-2-oxobutanoate and acetyl-CoA to 2-isopropylmalate. LeuA participates in the biosynthesis of leucine and pyruvate metabolism[1]. Disease Relevance Structural highlights

3D structures of 2-isopropylmalate synthase

Updated on 19-December-2016

References

1. ↑ de Carvalho LP, Blanchard JS. Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Biochemistry. 2006 Jul 25;45(29):8988-99. PMID:16846242 doi:http://dx.doi.org/10.1021/bi0606602