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Latrophilin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> describing Jmol <ref>PMID:21638687</ref> to the rescue. == Function == '''Latrophilin...) |
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| + | <StructureSection load='5cmn' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
'''Latrophilin''' (LAT) or '''adhesion G protein-coupled receptor''' is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates<ref>PMID:21618826</ref>. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter. | '''Latrophilin''' (LAT) or '''adhesion G protein-coupled receptor''' is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates<ref>PMID:21618826</ref>. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter. | ||
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== Disease == | == Disease == | ||
| - | + | LAT-3 variant confers susceptibility to ADHD and predicts effectiveness of stimulant medication<ref>PMID:20157310</ref>. | |
| - | + | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
| + | ==3D structures of lactophilin== | ||
| + | |||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| + | *Latrophilin-1 | ||
| + | |||
| + | **[[4dlq]] – LAT-1 GAIN and HORMR domains - rat<br /> | ||
| + | **[[2jx9]] – mLAT-1 Gal_lectin domain – mouse - NMR<br /> | ||
| + | **[[2jxa]] – mLAT-1 Gal_lectin domain + rhamnose - NMR<br /> | ||
| + | |||
| + | *Latrophilin-3 | ||
| + | |||
| + | **[[5ftt]], [[5ftu]] – hLAT-3 + FLRT2 + netrin receptor - human<br /> | ||
| + | **[[5cmn]] – hLAT-3 olfactomedin domain + FLRT3<br /> | ||
| + | **[[4yeb]] – mLAT-3 + FLRT3 <br /> | ||
| + | **[[4rmk]], [[4rml]] – hLAT-3 olfactomedin domain<br /> | ||
| + | **[[5afb]] – hLAT-3 olfactomedin and lectin domains<br /> | ||
| + | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 09:32, 21 December 2016
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3D structures of lactophilin
Updated on 21-December-2016
References
- ↑ Silva JP, Ushkaryov YA. The latrophilins, "split-personality" receptors. Adv Exp Med Biol. 2010;706:59-75. PMID:21618826
- ↑ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domene S, Velez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. doi: 10.1038/mp.2010.6. Epub 2010 Feb, 16. PMID:20157310 doi:http://dx.doi.org/10.1038/mp.2010.6
