2mn2
From Proteopedia
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==3D structure of YmoB, a modulator of biofilm formation== | ==3D structure of YmoB, a modulator of biofilm formation== | ||
<StructureSection load='2mn2' size='340' side='right' caption='[[2mn2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2mn2' size='340' side='right' caption='[[2mn2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mn2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MN2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mn2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MN2 FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mn2 RCSB], [http://www.ebi.ac.uk/pdbsum/2mn2 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn2 OCA], [http://pdbe.org/2mn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mn2 RCSB], [http://www.ebi.ac.uk/pdbsum/2mn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mn2 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB can replace TomB as antitoxins in E. coli. In contrast to other TA systems, [C117S]YmoB transiently interacts with Hha (rather than forming a stable complex) and enhances the spontaneous oxidation of the Hha conserved cysteine residue to a -SOxH-containing species (sulfenic, sulfinic or sulfonic acid), which destabilizes the toxin. The nuclear magnetic resonance structure of [C117S]YmoB and the homology model of TomB show that the two proteins form a four-helix bundle with a conserved buried cysteine connected to the exterior by a channel with a diameter comparable to that of an oxygen molecule. The Hha interaction site is located on the opposite side of the helix bundle. | ||
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| + | An oxygen-sensitive toxin-antitoxin system.,Marimon O, Teixeira JM, Cordeiro TN, Soo VW, Wood TL, Mayzel M, Amata I, Garcia J, Morera A, Gay M, Vilaseca M, Orekhov VY, Wood TK, Pons M Nat Commun. 2016 Dec 8;7:13634. doi: 10.1038/ncomms13634. PMID:27929062<ref>PMID:27929062</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2mn2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 14:10, 22 December 2016
3D structure of YmoB, a modulator of biofilm formation
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