1r09
From Proteopedia
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|PDB= 1r09 |SIZE=350|CAPTION= <scene name='initialview01'>1r09</scene>, resolution 2.9Å | |PDB= 1r09 |SIZE=350|CAPTION= <scene name='initialview01'>1r09</scene>, resolution 2.9Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=JEN:3-METHOXY-6-[4-(3-METHYLPHENYL)-1-PIPERAZINYL]PYRIDAZINE'>JEN | + | |LIGAND= <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JEN:3-METHOXY-6-[4-(3-METHYLPHENYL)-1-PIPERAZINYL]PYRIDAZINE'>JEN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r09 OCA], [http://www.ebi.ac.uk/pdbsum/1r09 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r09 RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R09 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1R09 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R09 OCA]. |
==Reference== | ==Reference== | ||
Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1847215 1847215] | Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1847215 1847215] | ||
| - | [[Category: Human rhinovirus | + | [[Category: Human rhinovirus 14]] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Andries, K.]] | [[Category: Andries, K.]] | ||
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[[Category: Minor, I.]] | [[Category: Minor, I.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
| - | [[Category: DMS]] | ||
| - | [[Category: JEN]] | ||
[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
[[Category: rhinovirus coat protein]] | [[Category: rhinovirus coat protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:22 2008'' |
Revision as of 20:21, 30 March 2008
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| , resolution 2.9Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837
Overview
The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible.
About this Structure
1R09 is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.
Reference
Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:1847215
Page seeded by OCA on Sun Mar 30 23:21:22 2008
