1r1a
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1a OCA], [http://www.ebi.ac.uk/pdbsum/1r1a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r1a RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R1A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1R1A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_1a Human rhinovirus 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1A OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of human rhinovirus serotype 1A (HRV1A)., Kim SS, Smith TJ, Chapman MS, Rossmann MC, Pevear DC, Dutko FJ, Felock PJ, Diana GD, McKinlay MA, J Mol Biol. 1989 Nov 5;210(1):91-111. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2555523 2555523] | Crystal structure of human rhinovirus serotype 1A (HRV1A)., Kim SS, Smith TJ, Chapman MS, Rossmann MC, Pevear DC, Dutko FJ, Felock PJ, Diana GD, McKinlay MA, J Mol Biol. 1989 Nov 5;210(1):91-111. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2555523 2555523] | ||
| - | [[Category: Human rhinovirus | + | [[Category: Human rhinovirus 1a]] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Kim, S.]] | [[Category: Kim, S.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
| - | [[Category: SUC]] | ||
[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
[[Category: rhinovirus coat protein]] | [[Category: rhinovirus coat protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:51 2008'' |
Revision as of 20:21, 30 March 2008
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| , resolution 3.2Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS SEROTYPE 1A (HRV1A)
Overview
The structure of human rhinovirus 1A (HRV1A) has been determined to 3.2 A resolution using phase refinement and extension by symmetry averaging starting with phases at 5 A resolution calculated from the known human rhinovirus 14 (HRV14) structure. The polypeptide backbone structures of HRV1A and HRV14 are similar, but the exposed surfaces are rather different. Differential charge distribution of amino acid residues in the "canyon", the putative receptor binding site, provides a possible explanation for the difference in minor versus major receptor group specificities, represented by HRV1A and HRV14, respectively. The hydrophobic pocket in VP1, into which antiviral compounds bind, is in an "open" conformation similar to that observed in drug-bound HRV14. Drug binding in HRV1A does not induce extensive conformational changes, in contrast to the case of HRV14.
About this Structure
1R1A is a Protein complex structure of sequences from Human rhinovirus 1a. Full crystallographic information is available from OCA.
Reference
Crystal structure of human rhinovirus serotype 1A (HRV1A)., Kim SS, Smith TJ, Chapman MS, Rossmann MC, Pevear DC, Dutko FJ, Felock PJ, Diana GD, McKinlay MA, J Mol Biol. 1989 Nov 5;210(1):91-111. PMID:2555523
Page seeded by OCA on Sun Mar 30 23:21:51 2008
