1r1n
From Proteopedia
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|PDB= 1r1n |SIZE=350|CAPTION= <scene name='initialview01'>1r1n</scene>, resolution 1.74Å | |PDB= 1r1n |SIZE=350|CAPTION= <scene name='initialview01'>1r1n</scene>, resolution 1.74Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CN1:OXO-IRON+CLUSTER+2'>CN1</scene>, <scene name='pdbligand=CNB:OXO-IRON+CLUSTER+1'>CNB</scene>, <scene name='pdbligand=CNF:OXO-IRON+CLUSTER+3'>CNF</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1o7t|1O7T]], [[1d91|1D91]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1n OCA], [http://www.ebi.ac.uk/pdbsum/1r1n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r1n RCSB]</span> | ||
}} | }} | ||
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[[Category: Sadler, P J.]] | [[Category: Sadler, P J.]] | ||
[[Category: Zhu, H.]] | [[Category: Zhu, H.]] | ||
| - | [[Category: CN1]] | ||
| - | [[Category: CNB]] | ||
| - | [[Category: CNF]] | ||
[[Category: iron binding protein]] | [[Category: iron binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:57 2008'' |
Revision as of 20:21, 30 March 2008
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| , resolution 1.74Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1O7T, 1D91
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae
Overview
We report a set of three 1.8-1.9 A resolution X-ray crystal structures of Neisseria gonorrhoeae Fbp (ferric-ion binding protein): (i) open-cleft apo-Fbp containing bound phosphate, (ii) open-cleft mono-Fe Fbp capped by nitrilotriacetate, and (iii) open-cleft trinuclear oxo-iron Fbp, the first structure of an iron-cluster adduct of a transferrin. The nine independent molecules in the unit cells provide 'snapshots' of the versatile dynamic structural roles of the conserved dityrosyl iron-binding motif (Tyr195-Tyr196) which control the capture and, possibly, processing of iron. These findings have implications for understanding bacterial iron acquisition and dissimilation, and organic/mineral interfaces.
About this Structure
1R1N is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.
Reference
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif., Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ, Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:13129433
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