1r2q
From Proteopedia
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|PDB= 1r2q |SIZE=350|CAPTION= <scene name='initialview01'>1r2q</scene>, resolution 1.05Å | |PDB= 1r2q |SIZE=350|CAPTION= <scene name='initialview01'>1r2q</scene>, resolution 1.05Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= RAB5A OR RAB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= RAB5A OR RAB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1n6h|1N6H]], [[1n6i|1N6I]], [[1n6k|1N6K]], [[1n6l|1N6L]], [[1n6n|1N6N]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2q OCA], [http://www.ebi.ac.uk/pdbsum/1r2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r2q RCSB]</span> | ||
}} | }} | ||
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[[Category: Zhang, X C.]] | [[Category: Zhang, X C.]] | ||
[[Category: Zhu, G.]] | [[Category: Zhu, G.]] | ||
| - | [[Category: GNP]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: MG]] | ||
[[Category: atomic resolution]] | [[Category: atomic resolution]] | ||
[[Category: gnp]] | [[Category: gnp]] | ||
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[[Category: rab]] | [[Category: rab]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:22:27 2008'' |
Revision as of 20:22, 30 March 2008
| |||||||
| , resolution 1.05Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | RAB5A OR RAB5 (Homo sapiens) | ||||||
| Related: | 1N6H, 1N6I, 1N6K, 1N6L, 1N6N
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution
Overview
Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.
About this Structure
1R2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution., Terzyan S, Zhu G, Li G, Zhang XC, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):54-60. Epub 2003, Dec 18. PMID:14684892
Page seeded by OCA on Sun Mar 30 23:22:27 2008
Categories: Homo sapiens | Single protein | Li, G. | Terzyan, S. | Zhang, X C. | Zhu, G. | Atomic resolution | Gnp | Gtpase | Rab
