5h1c

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'''Unreleased structure'''
 
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The entry 5h1c is ON HOLD until Paper Publication
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==Human RAD51 post-synaptic complexes==
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<StructureSection load='5h1c' size='340' side='right' caption='[[5h1c]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5h1c]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H1C FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h1b|5h1b]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h1c OCA], [http://pdbe.org/5h1c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h1c RCSB], [http://www.ebi.ac.uk/pdbsum/5h1c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h1c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/RAD51_HUMAN RAD51_HUMAN]] Defects in RAD51 are a cause of susceptibility to breast cancer (BC) [MIM:[http://omim.org/entry/114480 114480]]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.<ref>PMID:10807537</ref> Defects in RAD51 are the cause of mirror movements type 2 (MRMV2) [MIM:[http://omim.org/entry/614508 614508]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:22305526</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/RAD51_HUMAN RAD51_HUMAN]] Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.<ref>PMID:18417535</ref> <ref>PMID:12205100</ref> <ref>PMID:20413593</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Sung, P]]
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[[Category: Wang, H W]]
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[[Category: Xu, J]]
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[[Category: Xu, Y]]
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[[Category: Zhao, L]]
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[[Category: Zhao, W]]
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[[Category: Atpase]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna repair]]
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[[Category: Homologous recombination]]

Revision as of 21:39, 22 December 2016

Human RAD51 post-synaptic complexes

5h1c, resolution 4.50Å

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