5l6y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==il13 in complex with tralokinumab== | |
| - | + | <StructureSection load='5l6y' size='340' side='right' caption='[[5l6y]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l6y]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L6Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l6y OCA], [http://pdbe.org/5l6y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l6y RCSB], [http://www.ebi.ac.uk/pdbsum/5l6y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l6y ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Breed, J]] | ||
| + | [[Category: Il13]] | ||
| + | [[Category: Il13 antibody tralokinumab asthma]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 21:43, 22 December 2016
il13 in complex with tralokinumab
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