5tjw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody== | |
| - | + | <StructureSection load='5tjw' size='340' side='right' caption='[[5tjw]], [[Resolution|resolution]] 3.23Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tjw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TJW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjw OCA], [http://pdbe.org/5tjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tjw RCSB], [http://www.ebi.ac.uk/pdbsum/5tjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjw ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B4URF1_9INFA B4URF1_9INFA]] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.[SAAS:SAAS00107710] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hanke, L]] | ||
| + | [[Category: Knockenhauer, K E]] | ||
| + | [[Category: Ploegh, H L]] | ||
| + | [[Category: Schwartz, T U]] | ||
| + | [[Category: Influenza]] | ||
| + | [[Category: Inhibitory]] | ||
| + | [[Category: Nucleoprotein]] | ||
| + | [[Category: Vhh]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 21:46, 22 December 2016
Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody
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