5tjx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human plasma kallikrein== | |
| - | + | <StructureSection load='5tjx' size='340' side='right' caption='[[5tjx]], [[Resolution|resolution]] 1.41Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tjx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TJX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBT:(8E)-3-AMINO-1-METHYL-15-[(1H-PYRAZOL-1-YL)METHYL]-7,10,11,12,24,25-HEXAHYDRO-6H,18H,23H-19,22-(METHENO)PYRIDO[4,3-J][1,9,13,17,18]BENZODIOXATRIAZACYCLOHENICOSIN-23-ONE'>GBT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjx OCA], [http://pdbe.org/5tjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tjx RCSB], [http://www.ebi.ac.uk/pdbsum/5tjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjx ProSAT]</span></td></tr> |
| - | [[Category: Choy, R | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[http://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Plasma kallikrein]] | ||
| + | [[Category: Choy, R M]] | ||
[[Category: Li, Z]] | [[Category: Li, Z]] | ||
| + | [[Category: Partridge, J R]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Serine]] | ||
Revision as of 21:46, 22 December 2016
Structure of human plasma kallikrein
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