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4cz7

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Revision as of 07:21, 23 December 2016

Truncated tetramerization domain of zebrafish p53 (crystal form III)

Structural highlights

4cz7 is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	4cz5, 4cz6
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[G1K2L5_DANRE] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).[RuleBase:RU003304]

Publication Abstract from PubMed

The tetrameric transcription factors p53, p63, and p73 evolved from a common ancestor and play key roles in tumor suppression and development. Surprisingly, p63 and p73 require a second helix in their tetramerization domain for the formation of stable tetramers that is absent in human p53, raising questions about the evolutionary processes leading to diversification. Here we determined the crystal structure of the zebrafish p53 tetramerization domain, which contains a second helix, reminiscent of p63 and p73, combined with p53-like features. Through comprehensive phylogenetic analyses, we systematically traced the evolution of vertebrate p53 family oligomerization domains back to the beginning of multicellular life. We provide evidence that their last common ancestor also had an extended p63/p73-like domain and pinpoint evolutionary events that shaped this domain during vertebrate radiation. Domain compaction and transformation of a structured into a flexible, intrinsically disordered region may have contributed to the expansion of the human p53 interactome.

Tracing the Evolution of the p53 Tetramerization Domain.,Joerger AC, Wilcken R, Andreeva A Structure. 2014 Sep 2;22(9):1301-10. doi: 10.1016/j.str.2014.07.010. PMID:25185827^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Joerger AC, Wilcken R, Andreeva A. Tracing the Evolution of the p53 Tetramerization Domain. Structure. 2014 Sep 2;22(9):1301-10. doi: 10.1016/j.str.2014.07.010. PMID:25185827 doi:http://dx.doi.org/10.1016/j.str.2014.07.010

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cz7"

Categories: Joerger, A C | Cell cycle | Danio rerio | Transcription factor protein evolution | Tumor suppressor

@@ Line 1: / Line 1: @@
 ==Truncated tetramerization domain of zebrafish p53 (crystal form III)==
 <StructureSection load='4cz7' size='340' side='right' caption='[[4cz7]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cz5|4cz5]], [[4cz6|4cz6]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4cz7 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cz7 OCA], [http://pdbe.org/4cz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4cz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cz7 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4cz7" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>

4cz7

From Proteopedia

Revision as of 07:21, 23 December 2016

Truncated tetramerization domain of zebrafish p53 (crystal form III)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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