1r5i
From Proteopedia
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|PDB= 1r5i |SIZE=350|CAPTION= <scene name='initialview01'>1r5i</scene>, resolution 2.60Å | |PDB= 1r5i |SIZE=350|CAPTION= <scene name='initialview01'>1r5i</scene>, resolution 2.60Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5i OCA], [http://www.ebi.ac.uk/pdbsum/1r5i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r5i RCSB]</span> | ||
}} | }} | ||
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[[Category: Mourad, W.]] | [[Category: Mourad, W.]] | ||
[[Category: Zhao, Y.]] | [[Category: Zhao, Y.]] | ||
| - | [[Category: PO4]] | ||
[[Category: complex]] | [[Category: complex]] | ||
[[Category: mam]] | [[Category: mam]] | ||
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[[Category: superantigen]] | [[Category: superantigen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:23:30 2008'' |
Revision as of 20:23, 30 March 2008
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| , resolution 2.60Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the MAM-MHC complex
Overview
Mycoplasma arthritidis-derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing particular TCR Vbeta elements. Here we report the crystal structure of MAM complexed with a major histocompatibility complex (MHC) antigen, HLA-DR1, loaded with haemagglutinin peptide 306-318 (HA). The structure reveals that MAM has a novel fold composed of two alpha-helical domains. This fold is entirely different from that of the pyrogenic superantigens, consisting of a beta-grasped motif and a beta barrel. In the complex, the N-terminal domain of MAM binds orthogonally to the MHC alpha1 domain and the bound HA peptide, and to a lesser extent to the MHC beta1 domain. Two MAM molecules form an asymmetric dimer and cross-link two MHC antigens to form a plausible, dimerized MAM-MHC complex. These data provide the first crystallographic evidence that superantigens can dimerize MHC molecules. Based on our structure, a model of the TCR2MAM2MHC2 complex is proposed.
About this Structure
1R5I is a Protein complex structure of sequences from Homo sapiens and Mycoplasma arthritidis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex., Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H, Structure. 2004 Feb;12(2):277-88. PMID:14962388
Page seeded by OCA on Sun Mar 30 23:23:30 2008
Categories: Homo sapiens | Mycoplasma arthritidis | Protein complex | Drozd, S J. | Guo, Y. | Li, H. | Li, Z. | Mourad, W. | Zhao, Y. | Complex | Mam | Mhc | Superantigen
