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Thrombospondin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The arginine side chains of the N-terminal interact with the heparin sulfate groups<ref>PMID:16407063</ref>. | + | The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The <scene name='74/748873/Cv/2'arginine and lysine side chains of the N-terminal interact with the heparin sulfate groups</scene><ref>PMID:16407063</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 09:11, 25 December 2016
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3D structures of thrombospondin
Updated on 25-December-2016
References
- ↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
- ↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:http://dx.doi.org/10.1101/cshperspect.a006627
- ↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200
