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Siderocalin
From Proteopedia
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| + | <StructureSection load='4zfx' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' > | ||
| + | == Function == | ||
| + | Siderocalin (Scn) binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | ||
| + | == Relevance == | ||
| + | Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death<ref>PMID:22728330</ref>. | ||
| + | |||
| + | </StructureSection> | ||
| + | ==3D structures of siderocalin== | ||
| + | |||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| + | *Siderocalin or lipocalin-2 | ||
| + | |||
| + | **[[5jr8]], [[3bx8]] – hScn NGAL - human<br /> | ||
| + | **[[3s26]] – mScn NGAL - mouse<br /> | ||
| + | **[[2kt4]] – qScn Q83 – quail<br /> | ||
| + | |||
| + | *Siderocalin complex | ||
| + | |||
| + | **[[4mvi]], [[4mvk]], [[4mvl]] – hScn NGAL (mutant) + beta amyloid protein 40 peptide<br /> | ||
| + | **[[3bx7]] – hScn NGAL + CTLA-4<br /> | ||
| + | **[[3tzs]] – hScn NGAL (mutant) + phenylurea<br /> | ||
| + | **[[4zfx]], [[4zhc]], [[4zhd]], [[4zhf]], [[4zhg]], [[4zhh]], [[4qae]], [[4k19]], [[4aiw]], [[4aix]], [[3u03]], [[3u0d]], [[3k3l]], [[3dsz]], [[1x89]], [[1x8u]], [[1x71]] – hScn NGAL + siderophore<br /> | ||
| + | **[[3tf6]], [[3t1d]], [[3i0a]], [[3hwd]] – hScn NGAL (mutant) + siderophore<br /> | ||
| + | **[[3pec]], [[3ped]] – hScn NGAL + siderophore + Fe<br /> | ||
| + | **[[3hwe]], [[3hwf]], [[3hwg]], [[3cmp]], [[3by0]], [[3cbc]] – hScn NGAL (mutant) + siderophore + Fe<br /> | ||
| + | **[[3fw4]], [[3fw5]] – hScn NGAL (mutant) + catechol + Fe<br /> | ||
| + | **[[4gh7]] – hScn NGAL + fibronectin<br /> | ||
| + | **[[3u9p]] – mScn NGAL + Fab <br /> | ||
| + | **[[2lbv]] – qScn Q83 + enterobactin – NMR<br /> | ||
| + | **[[3sao]] – cScn + myristoyl lysophosphatidic acid - chicken<br /> | ||
| + | > | ||
| + | |||
| + | }} | ||
| + | ==References== | ||
| + | <references /> | ||
| + | |||
| + | [[Category:Topic Page]] | ||
Revision as of 09:21, 25 December 2016
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3D structures of siderocalin
Updated on 25-December-2016
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References
- ↑ Hoette TM, Abergel RJ, Xu J, Strong RK, Raymond KN. The role of electrostatics in siderophore recognition by the immunoprotein Siderocalin. J Am Chem Soc. 2008 Dec 24;130(51):17584-92. doi: 10.1021/ja8074665. PMID:19053425 doi:http://dx.doi.org/10.1021/ja8074665
- ↑ Paragas N, Qiu A, Hollmen M, Nickolas TL, Devarajan P, Barasch J. NGAL-Siderocalin in kidney disease. Biochim Biophys Acta. 2012 Sep;1823(9):1451-8. doi: 10.1016/j.bbamcr.2012.06.014., Epub 2012 Jun 19. PMID:22728330 doi:http://dx.doi.org/10.1016/j.bbamcr.2012.06.014
