Aldo-keto reductase

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<StructureSection load='1kcf' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' >
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== Function ==
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Aldo-keto reductase (AKR) is a protein family which contains enzyme that reduce carbonyl substrates like sugar aldehyde, keto-steroid, keto-prostaglandin, retinal, quinones and lipid peroxidation by-products to primary alcohol<ref>PMID:25304492</ref>. AKR uses NADP as a cofactor. AKR contain a conserved catalytic tetrad consisting of Tyr, Asp, Lys and His.
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== Disease ==
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Mutations in AKR1D1 cause a form of bile acid deficiency which can be fatal in newborns<ref>PMID:20522910</ref>.
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==3D structures of aldo-keto reductase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*AKR1B1
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**[[2j8t]] – hAKR1B1 + NADP - human<br />
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*AKR1B4
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**[[4hbq]] – AKR1B4 – blood fluke<br />
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*AKR1B10
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**[[4xzm]] – hAKR1B10 + NADP <br />
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**[[4xzn]] – hAKR1B10 (mutant) + NADP <br />
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**[[4jih]], [[4jii]], [[4i5x]] – hAKR1B10 + NADP + inhibitor <br />
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**[[4ga8]], [[4gab]], [[1zua]], [[5liy]], [[5lik]], [[5liu]], [[5liw]], [[5lix]], [[4xzl]], [[4wev]], [[4icc]] – hAKR1B10 (mutant) + NADP + inhibitor <br />
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**[[4gq0]] – hAKR1B10 + NADP + caffeic acid ester<br />
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*AKR1B14
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**[[3o3r]] – rAKR1B14 + NADP - rat<br />
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**[[3qkz]] – rAKR1B14 (mutant) + NADP <br />
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*AKR1C1
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See [[Hydroxysteroid dehydrogenase]] 20-alpha HSD
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*AKR1C2 or 3-alpha hydroxysteroid dehydrogenase
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See [[Hydroxysteroid dehydrogenase]] 3-alpha HSD
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*AKR1C3
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See [[Prostaglandin F synthase]]
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*AKR1C4
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**[[2fvl]] – hAKR1C4 + NADP <br />
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*AKR1C21 or 17-alpha hydroxysteroid dehydrogenase
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See [[Hydroxysteroid dehydrogenase]] 17-alpha HSD
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*AKR1D1 or 3-oxo-5-beta-steroid 4-dehydrogenase
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**[[3caq]], [[3buv]], [[3bv7]] – hAKR1D1 + NADP <br />
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**[[3dop]] – hAKR1D1 + NADP + 5-beta-dehydrotestosterone<br />
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**[[3uzy]] – hAKR1D1 (mutant) + NADP + 5-beta-dehydrotestosterone<br />
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**[[3bur]] – hAKR1D1 (mutant) + NADP + testosterone<br />
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**[[3uzz]] – hAKR1D1 (mutant) + NADP + 5-delta-androstenedione<br />
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**[[3cas]] – hAKR1D1 + NADP + 4-androstenedione<br />
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**[[3g1r]] – hAKR1D1 + NADP + finasteride<br />
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**[[3cav]] – hAKR1D1 + NADP + 5-beta-pregnan-3,20-dione<br />
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**[[3cmf]] – hAKR1D1 + NADP + cortisone<br />
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**[[3cot]] – hAKR1D1 + NADP + progesterone<br />
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*AKR2E4
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**[[3wcz]] – AKR2E4 + NADP – silk moth<br />
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*AKR4C8
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**[[3h7r]] – AtAKR4C8 + NADP – ''Arabidopsis thaliana''<br />
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*AKR4C9
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**[[3h7u]] – AtAKR4C8 + NADP <br />
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*AKR7A1 or aflatoxin aldehyde reductase
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**[[1gve]] – AKR7A1 + NADP – rat<br />
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*AKR11A or IOLS protein
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**[[1pyf]] – BsAKR11A – ''Bacillus subtilis'' <br />
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**[[1pz0]] – BsAKR11A + NADP <br />
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*AKR11B or general stress protein 69
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**[[1pz1]] – BsAKR11B + NADP <br />
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*AKR11B4
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**[[3n2t]] – AKR11B4 – ''Gluconobacter oxydans'' <br />
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*AKR11C1
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**[[1ynp]] – BhAKR11C1 – ''Bacillus halodurans'' <br />
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**[[1ynq]] – BhAKR11C1 + NADP <br />
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*AKR14A1
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**[[4ast]] – EcAKR14A1 – ''Escherichia coli''<br />
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**[[4aub]] – EcAKR14A1 + NADP <br />
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*AKR
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**[[4xap]] – RmAKR – ''Rhizobium meliloti''<br />
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**[[5c7h]] – RmAKR + NADP <br />
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**[[4xk2]] – AKR – ''Polaromonas''<br />
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**[[4wgh]] – AKR (mutant) + NADP – ''Klebsiella pneumoniae''<br />
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**[[3n6q]] – EcAKR <br />
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**[[3o0k]] – AKR – ''Brucella melitensis''<br />
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**[[2wzt]] – MsAKR – ''Mycobacterium smegmatis''<br />
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**[[2wzm]] – MsAKR + ligand<br />
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]]
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==References==
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<references />
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[[Category:Topic Page]]

Revision as of 10:57, 28 December 2016

Yeast Holliday junction resolvase dimer complex with sulfate, 1kcf

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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