Aldo-keto reductase
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
*'''AKR1B10''' reduces aliphatic and aromatic aldehydes. It is expressed in adrenal gland, small intestines and colon.<br /> | *'''AKR1B10''' reduces aliphatic and aromatic aldehydes. It is expressed in adrenal gland, small intestines and colon.<br /> | ||
| - | *'''AKRB14''' is involved in | + | *'''AKRB14''' is involved in synthesis of prostaglandin F and detoxification of products of lipid peroxidation.<br /> |
*'''AKR1D1''' is responsible for the catalysis of 5-β-reduction of bile acid intermediates and steroid hormones carrying a δ(4)-3-one structure.<br /> | *'''AKR1D1''' is responsible for the catalysis of 5-β-reduction of bile acid intermediates and steroid hormones carrying a δ(4)-3-one structure.<br /> | ||
| Line 10: | Line 10: | ||
Mutations in AKR1D1 cause a form of bile acid deficiency which can be fatal in newborns<ref>PMID:20522910</ref>. | Mutations in AKR1D1 cause a form of bile acid deficiency which can be fatal in newborns<ref>PMID:20522910</ref>. | ||
| - | + | ==Structural highlights == | |
| - | + | The active site of AKR1B10 contains the cofactor NADP and a polyfluorinated inhibitor. Tyr and His are part of the enzyme catalytic tetrad<ref>PMID:24598757</ref>. | |
==3D structures of aldo-keto reductase== | ==3D structures of aldo-keto reductase== | ||
Revision as of 11:36, 28 December 2016
| |||||||||||
